Titre du document

Comparaisons des effets de l'apomorphine et de la naloxone chez des rats et des souris en état de dépendance aiguë a la morphine

Nom du corpus

Corpus Unitex français

Lien vers le document
Auteur(s)
  • Evelyne C. Tremblay 1
  • Joseph J. Jacob 1
Affiliation(s)
  • 1) Service de Pharmacologie de l'Institut Pasteur, 28, rue du Dr. Roux, F-75724, Paris Cedex, France
Revue

Psychopharmacology

Langue(s) du document
Français
Éditeur
Springer (journals)
Année de publication
1978
Type de publication
Journal
Type de document
Research-article
Résumé

The actions of acute morphinization on the behavioural signs induced by apomorphine have been studied in rats and in two strains of mice with various doses of morphine and time-intervals also used for naloxone-precipitated abstinence. In naive rats, some of the effects of apomorphine but not all of them resembled signs of abstinence; some of these latter were not observed after apomorphine alone. Acute morphinization decreased or increased the frequencies of various effects of apomorphine, depending on the particular sign and time-schedule; these modifications were antagonized by naloxone. Depressions were observed for most of the signs, shortly after the administration of morphine. Increases appeared for only some signs either early or late but the increased effects were not abstinence-like signs. In naive mice, apomorphine produced infrequent jumping, an abstinence-like sign; acute morphinization enhanced it considerably. This phenomenon was antagonized by naloxone; its time-course was not quite identical to that of abstinence. In morphinized mice, the jumping produced by apomorphine was antagonized by low doses of various neuroleptics (haloperidol, chlorpromazine, pimozide and benperidol) whereas in the same conditions the jumping precipited by naloxone was not antagonized even by high doses of haloperidol or chlorpromazine, pimozide being effective in only one of the two strains. Benperidol was the less discriminating neuroleptic; its efficacy on naloxone-precipitated jumping might be related to its affinity for opiate receptor, as described in the literature. Naloxone-precipitated jumping was also not antagonized by ?-MT. These results, especially those obtained in the mice, do not favor the conception that the studied abstinence-signs have a dopaminergic mechanism, even when apomorphine produced apparently similar effects.

Mots-clés d'auteur
  • Morphine
  • Apomorphine
  • Naloxone
  • Acute dependence
  • Neuroleptic
  • ?-Methyl-p-tyrosine
Catégories WoS
  • 1 - social science
  • 2 - psychiatry
  • 1 - science
  • 2 - pharmacology & pharmacy
  • 1 - science
  • 2 - neurosciences
Catégories Science-Metrix
  • 1 - health sciences
  • 2 - clinical medicine
  • 3 - psychiatry
Catégories Scopus
  • 1 - Life Sciences ; 2 - Pharmacology, Toxicology and Pharmaceutics ; 3 - Pharmacology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences medicales
  • 4 - psychopathologie. psychiatrie
persName
  • Von Pirquet
  • Hippocrate
  • Moneret-Vautrin
placeName
  • Royaume-Uni
  • États-Unis
  • États-Unis
  • Royaume-Uni
  • France
  • États-Unis
  • France
  • pays Européens
  • États-Unis
  • France
  • pays Scandinaves
  • Asie
  • Europe
  • États-Unis
  • Europe
  • Asie
  • Brésil
  • Brésil
  • États-Unis
  • Europe
  • pays nordiques
  • Japon
  • Japon
orgName
  • Cercle d’investigations cliniques et biologiques en allergologie alimentaire
  • CICBAA
  • International Life Science Institute
  • ILSI
  • Europe Food Allergy Task Force
  • ILSI
  • Europe Food Allergy Task Force
Date
  • 1906
  • 1963
  • 1921
  • 1980
  • 1993
Ref type bibl
  • [1]
  • Prausnitz et Küstner [2]
  • [3]
  • [4]
  • [5]
  • [6]
  • [7, 8]
  • [9, 10]
  • [11]
  • [12]
  • [13, 14]
  • [15]
  • [16]
  • [16, 17]
  • [18-20]
  • [21]
  • [22]
  • [23]
  • [24]
  • [25]
  • [25-27]
  • [28]
  • [23]
  • [29]
  • [20, 30]
  • [31]
  • [32]
  • [33]
  • [34]
  • [9, 35]
  • [20]
  • [36]
  • [36]
  • [10, 37]
  • [36]
  • [10]
  • [10, 37-39]
  • [40]
  • [36]
  • [36]
  • [10]
  • [41, 42]
  • [43, 44]
  • [45]
  • [46]
  • [38]
  • [47]
  • [48, 49]
  • [50]
  • [31]
  • [31, 142]
  • [51]
  • [52]
  • [53]
  • [54]
  • [55]
  • [56]
  • [57]
  • [58]
  • [36, 59]
  • [51]
  • [60]
  • [113]
  • [61, 62]
  • [63]
  • [64]
  • [65]
  • [66]
  • [67]
  • [68, 69]
  • [70]
  • [71, 72]
  • [73]
  • [53]
  • [74]
  • [53, 54]
  • [51]
  • [75]
  • [76]
  • [77]
  • [78]
  • [70]
  • [79]
  • [70]
  • [80]
  • [81]
  • [82]
  • [83]
  • [84]
  • [44]
  • [85, 86]
  • [85]
  • [86]
  • [87]
  • [88]
  • [89, 90]
  • [91]
  • [51, 92]
  • [51, 92]
  • [76, 77, 93-95]
  • [51]
  • [3, 92, 96]
  • [51]
  • [97]
  • [98]
  • [51]
  • [98]
  • [99]
  • [76, 94, 97]
  • [100]
  • [38]
  • [3]
  • [101]
  • [85]
  • [47]
  • [102]
  • [47]
  • [95]
  • [104]
  • [48, 49]
  • [103]
  • [50]
  • [99, 105]
  • [51]
  • [80]
  • [106]
  • [107]
  • [108]
  • [32, 33]
  • [109]
  • [110]
  • [111]
  • [32, 33]
  • [32, 33]
  • [110]
  • [112]
  • [18-20]
  • [52]
  • [113]
  • [16]
  • [113]
  • [113, 141]
  • [52]
  • [114]
  • [61, 62]
  • [61, 62]
  • [12, 20]
  • Onorato et al. [115]
  • [116]
  • [113]
  • [113]
  • [16]
  • [113]
  • [117-121]
  • [122-125]
  • [126]
  • [127]
  • [128-130]
  • [131]
  • [81, 132]
  • [89, 90]
  • [133]
  • [51]
  • [51]
  • [98]
  • [134]
  • [126, 135]
  • [126]
  • [137]
  • [51]
  • [138]
  • [139]
  • [140]
  • [51]
  • [106, 107]
Version PDF
1.3
Score qualité du texte
10
Présence de XML structuré
Absent
Identifiant ISTEX
01739D6936AFC3E258DB1737624DC5CEAED87A28
PMID
ark:/67375/1BB-7BF8FH47-P
Powered by Lodex 9.3.8